Gene: Rbp1

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Name
retinol binding protein 1, cellular
MGI ID
MGI:97876
Synonyms
Crbp CRBPI Rbp-1
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Rbp1tm2b(EUCOMM)Hmgu HOM Early adult 2.00×10-05
decreased circulating serum albumin level Rbp1tm2b(EUCOMM)Hmgu HOM Late adult 4.17×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No  (1/2)  Wholemount images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No  (1/2)  Wholemount images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Echo: M-Mode Images
44 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
X-ray: XRay Images Whole Body Dorso Ventral
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Adult LacZ: LacZ Images Wholemount
2 Images

 Disease Models

  • The disease models module displays the analysis of phenotypic similarity between mouse and human. This can:
    • provide insight into the fidelity of the mouse knockout to a "solved" human disease,
    • suggest candidate genes for unsolved human diseases,
    • indicate possible genetic interactions between genes.
  • Phenodigm calculates similarity scores by comparing the IMPC mouse phenotypes to the clinical descriptions of human disease. Scores are weighted by the number and uniqueness of matches between mouse and human phenotype ontologies. The overall score is normalized to 100 as the best score.
  • The tab "By Phenotypic Similarity" derives from a global analysis of similarity between mouse and human diseases and syndromes, (using information from OMIM, Orphanet, and DECIPHER)
  • The tab "By Annotation and Orthology" includes only those cases where mutation(s) in the orthologous human gene cause disease, thereby measure phenotype similarity between mutations in the mouse and human gene.
  • To understand what expanding a row shows, visit documentation for disease models
  • A best match (high Phenodigm score) may occur with an orphan or "unsolved" disease, and this suggests the mouse gene as a candidate for the human disorder.
  • It is important to note that a mouse knockout may also have a high scoring match to a “solved” human genetic disease associated with a different gene. A genocopy suggests that the two genes may interact in a physiological pathway or network.
No associations by disease annotation and gene orthology found.
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MGI Allele Allele Type Produced
Rbp1tm2b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Rbp1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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